Don't tempt us with a good time

It won’t kill most of them the first time, just some. Health and wellness aren’t exactly the top priority for a lot of opioid addicts so it’s sort of effective marketing. If people are dying from it then it’s gotta be strong stuff.

Simply the stronger it is, the less you need to move, and the easier it is to smuggle.

Then you just cut it back to "standard" strength or attempt to do so. This is a big reason fentanyl displaced heroin, and why you see otherwise undesirable drugs like carfentanyl out there that are even stronger.

Vendors concerned about the long term outlook are generally discouraged by the possible jailtime. The ones we are left with tend to not give a shit about tomorrow.

Just gotta make it expensive enough to balance that out :)

fentanyl, from what I understand is quite useful in emergency rooms, I would imagine this might be similar.

Which is already 100 times as powerful as morphine, which is already super strong.

*In animal models.

For isotonitazene, which is related to etonitazene, activity in animal models is 1000 times as potent as morphine, while in humans, it's "only" 60 times as potent, according to Wikipedia.

The actual numbers for each I didn't find, but I guess that's because there were no human studies.

Isotonitazene is a benzimidazole-derived opioid analgesic drug related to etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans).