Microblog Memes

He's not the first one to 'kill his liver' with paracetamol/ acetominophen (tylenol). First case I recall, the person was taking tylenol nightly with a glass of wine. Here's some links on the current understanding of Liver injury and paracetamol:

Apparently it's not always overdosing: Paracetamol-induced hepatotoxicity at recommended dosage (https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2796.2003.01097.x)

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update (https://pmc.ncbi.nlm.nih.gov/articles/PMC4913076/) "...in the United States, in particular, it accounts for more than 50% of overdose-related acute liver failure and approximately 20% of the liver transplant cases."

Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults (https://www.mdpi.com/1648-9144/57/8/752) "In the univariable analysis, significant hepatotoxicity risk factors were male gender, alcohol abuse, an ingested paracetamol dose, and a timespan from ingestion to hospital admission. The later one was the only significant risk factor in the multivariable model (adjusted odds ratio 1.08; 95% CI: 1.03–1.12)."

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease (https://pubmed.ncbi.nlm.nih.gov/37436926/) "Where data were available, we estimate that paracetamol is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury."

Understanding paracetamol-induced liver failure (https://link.springer.com/article/10.1007/s00134-014-3293-9)

How big is a packet?

It's why in the UK shops won't sell more than 2 packets at a time. It's statistically reduced the amount of people killing themselves with them (intentionally or by mistake).

My daughter's dog that is a climber got on a shelf and knocked a basket off that had a large bottle of Tylenol in it. She chewed the bottle up.

I got home and saw some pills and a demolished bottle on the ground. Vet tech friend said to induce vomiting with hydrogen peroxide.

Didn't have any of that, but I did have some minty mouthwash with peroxide and no xylitol in it. Dog willingly drank it, puked with foam, drank a bit more, puked more foam, then I dug through the mess.

No pills or any sign of the color on the pills. She's still kicking.

ITT: People who don't know the difference between acute and chronic ODs and how a smaller amount over a long period can hurt you. 325mg APAP x4 will not kill you short term.

The problem was taking it every day over a long period.

Its still fucking stupid though.

Everyone's discussing ODing on OTC pain meds but the bigger part of this story is why he's in so much pain for so long without being able to see a Dr and receive treatment for chronic pain.

How much is a "packet"? edit: never mind, I found several conflicting answers in the other comments, no need to add even more and add to the confusion.

I mean... Yeah. There are instructions on the packet. They aren't supposed to be eaten like candy.

Isn't this why they specifically put acetaminophen in opioid+nsaid prescription painkillers, instead of ibuprofen or aspirin or naproxen? Just to discourage abuse because if you take too much it'll destroy your liver. Has always seemed a bit fucked up to me.