NAS drives come with a longer warranty and are a bit optimized for 24/7 operation. As to and SSD, if you need uptime, then RAID. SSD can fail just as an HDD. Also, keep in mind that RAID is not a backup. Also, with backups, ideally, follow the 3-2-1 rule: https://www.backblaze.com/blog/the-3-2-1-backup-strategy/

Speaking from experience, I would recommend any of the NAS/Enterprise disks over your run o'mill desktop disks anyday. In my first NAS (ReadyNAS Ultra 4) , all 4 disks died within 2 years. I replaced them with WD Reds and 10 years most are still going strong. I had one fail just last month after 88,959 hours of continuous use. Stuck in new disk and back to normal. I have WD Reds, Golds and a couple Ironwolfs too. All these drives are on 24/7, either in NAS or server configs.

Cheers

Exos X18 series are CMR drives for the enterprise server segment. They come with a 5 year warranty. They are perfectly fine in a NAS.