I completely agree with your last point. Why are we so stuck on the same ~150 years? (not counting Enterprise) Go to year 2600, start exploring things like AI singularities, the construction of megastructures like Dyson Spheres, artificial wormhole networks, or other more advanced sci-fi that was only scratched at in previous series.

Maybe have the series revolve around the first ship able to reach a neighboring galaxy and the new discoveries that await there. Isolated by extreme distance and forced to be self-sufficient, but not lost or unprepared like Voyager.

Or what if a competing coalition of species has started rapidly spreading from a different quadrant? Not one that's evil, but maybe one that just has a looser stance on things like The Prime Directive and Genetic Enhancement. What happens when member species of the Federation start getting lured away with promises of new technology and advancements?

What does Vulcan, or Romulus, look like when over half their population has decided to upload their consciousnesses into digital immortality? What does a free and democratic Ferenginar look like? How's the Gamma quadrant holding up with the power vacuum caused by disappearance of the Founders and the collapse of the Dominion?

Space is big, time is infinite, there's countless stories to be told somewhere outside of 2250-2400. New Trek should be looking forward, to new stories and new adventures; not backwards and trying to shoehorn in yet another prequel/remake without completely fucking up the canon.