this post was submitted on 05 May 2025
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Revolution in pain management: first non-opioid drug arrives (hive.blog)
submitted 1 month ago by Merlu@lemmy.ml to c/upliftingnews@lemmy.world
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[–] surfrock66@lemmy.world 107 points 1 month ago (2 children)

There's a lot of snark, but the idea is this only inhibits pain in the peripheries, so it isn't so psychoactively impacting. You don't get sedated, the addiction profile is way less, and the LD50 means OD'ing is much harder. I'm sure there's dependency potential, but it seems this is NOT recreational, which is huge, and if the sedation is less and you can take this and still function, it could be a game changer, allowing people impacted by chronic pain to re-enter the work force and have a better quality of life:

https://en.wikipedia.org/wiki/Suzetrigine https://pubmed.ncbi.nlm.nih.gov/39775738/

[–] surewhynotlem@lemmy.world 36 points 1 month ago (1 children)

For a moment I thought there was a drug called Recreationol. It sounded like a hell of a party.

[–] FistingEnthusiast@lemmynsfw.com 7 points 1 month ago (1 children)

I'd take it for sure

[–] blarghly@lemmy.world 4 points 1 month ago

A drug that gives you the feeling of bbqing with friends and family in the city park. Lit

[–] Guidy@lemmy.world 17 points 1 month ago

Hopefully it's not addictive, so maybe - just fucking maybe - people actually in pain can get it without jumping through a million hoops and being treated like drug-addicted criminals.

That'd be... neat.

[–] Trimatrix@lemmy.world 11 points 1 month ago (2 children)

I will bite. How much? Unless its cheaper than opiates, No one is going to put their profit margin above the common good of society.

[–] Mbourgon@lemmy.world 25 points 1 month ago (1 children)

“Vertex says that the medication will be available for $15.50 per 50-milligram pill, or about $30 per day. In contrast, comparable doses of the hydrocodone and acetaminophen combination retail for an average of about $7 per day.”

https://www.scientificamerican.com/article/what-is-journavx-the-new-opioid-free-painkiller-from-vertex/

[–] TheTechnician27@lemmy.world 15 points 1 month ago* (last edited 1 month ago) (1 children)

Alternative: send Vertex Pharmaceuticals' board to the guillotine and make the medication available for pennies per 50-milligram pill (at cost) or free (publicly funded).

[–] huppakee@lemm.ee 1 points 1 month ago (2 children)

Yes that will get people to do research and make new meds available. /s

[–] TheTechnician27@lemmy.world 21 points 1 month ago* (last edited 1 month ago) (2 children)

Should I have added "nationalize it and make future research funded and owned by the public"? (A lot of public funding already goes to medical research, but the profits get privatized.)

Private corporations researching medications so they can price gouge the chronically ill through a copyright-enforced monopoly isn't the only way to do medical research.

[–] Natanox@discuss.tchncs.de 2 points 1 month ago

That's the way.

[–] huppakee@lemm.ee -2 points 1 month ago

The public is definitely not benefitting enough from the research they fund als also the price gouging at the cost of sick people is very problematic, but I'm not in favour of beheading bad people. But I understand that the longer decision makers continue to allow these bad people to do these bad things, the more likely it becomes the guillotine makes an appearance.

[–] Doomsider@lemmy.world 4 points 1 month ago

Found the corporate bootlicker.

[–] Mouselemming@sh.itjust.works 9 points 1 month ago (1 children)

I think you (unintentionally) have that backwards. The companies absolutely will and do put their profit margin above the common good.

[–] Trimatrix@lemmy.world 2 points 1 month ago

Yeah…. My bad

[–] homesweethomeMrL@lemmy.world 8 points 1 month ago

What a weird site.

PR releases b/w standard blog fare and meta numbers discussion?

[–] Bluetreefrog@lemmy.world 7 points 1 month ago (1 children)

Aspirin has entered chat.

[–] ColeSloth@discuss.tchncs.de 3 points 1 month ago

Ah yes. The mild ache pain slightly less medication.

[–] ModestCrab@lemmy.wtf 6 points 1 month ago (4 children)

significantly more favorable side effect profile

So is this 3 days until an addiction starts vs the usual 2 days? Where’s the deets?

[–] 11111one11111@lemmy.world 17 points 1 month ago

It does but they didnt explain. It's the reduced impact on a person's brain that makes it less addictive by only blocking pain receptors at periphery locations and not in the brain. Removing the feeling of being high that opiates provide and just numbs the pain.

Journavx, which has been clinically proven to be as effective as opioids in the treatment of acute post-operative pain but with a significantly more favorable side effect profile. The drug blocks pain signals that are only found in the periphery, not in the brain, without the limitations of currently available therapies.

[–] don@lemm.ee 3 points 1 month ago (1 children)

There’s this at the bottom of the article. It may have what you’re looking for.

[–] ColeSloth@discuss.tchncs.de 2 points 1 month ago

I dont see it.

[–] DavidGarcia@feddit.nl 1 points 1 month ago (2 children)

I'll only make your dick fall off (and grow one first if you don't have one)

[–] Natanox@discuss.tchncs.de 5 points 1 month ago (1 children)

So it even doubles as non-invasive sex reassigment surgery precursor drug? Damn, this medicine is multifunctional as hell!

[–] captainlezbian@lemmy.world 1 points 1 month ago

The evolved form of spironolactone

[–] Laser@feddit.org 4 points 1 month ago

It's gonna be a huge success with Lemmy users

[–] captainlezbian@lemmy.world 4 points 1 month ago

Even if it had similar addiction profiles to opioids I'd be all for it. Opioid allergies are very common and those of us who have them also deserve to not be in agony after surgeries or physical trauma.

In fact, I worry that if its nonaddictive it may be pushed onto people who are allergic or nonresponsive to it similar to how nonstimulant adhd meds are. That doesn't mean I'm not all for nonaddictive painkillers, I'm 100% in favor and if we had a few options that can cover our bases I'd be in favor of shelving the poppy juice into a last resort role, but I hope people don't lose their sense of nuance in it.

[–] ripcord@lemmy.world 3 points 1 month ago

This does sound like great news.

[–] RizzRustbolt@lemmy.world 1 points 1 month ago

Is this BBB soluble like gabapentin?

[–] Swedneck@discuss.tchncs.de 1 points 1 month ago

so what, are normal pain relief pills opioids? or do they just not count as pain relief somehow?