this post was submitted on 05 May 2025
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Uplifting News

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Revolution in pain management: first non-opioid drug arrives (hive.blog)
submitted 2 months ago by Merlu@lemmy.ml to c/upliftingnews@lemmy.world
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[–] surfrock66@lemmy.world 107 points 2 months ago (2 children)

There's a lot of snark, but the idea is this only inhibits pain in the peripheries, so it isn't so psychoactively impacting. You don't get sedated, the addiction profile is way less, and the LD50 means OD'ing is much harder. I'm sure there's dependency potential, but it seems this is NOT recreational, which is huge, and if the sedation is less and you can take this and still function, it could be a game changer, allowing people impacted by chronic pain to re-enter the work force and have a better quality of life:

https://en.wikipedia.org/wiki/Suzetrigine https://pubmed.ncbi.nlm.nih.gov/39775738/

[–] surewhynotlem@lemmy.world 36 points 2 months ago (1 children)

For a moment I thought there was a drug called Recreationol. It sounded like a hell of a party.

[–] FistingEnthusiast@lemmynsfw.com 7 points 2 months ago (1 children)

I'd take it for sure

[–] blarghly@lemmy.world 4 points 2 months ago

A drug that gives you the feeling of bbqing with friends and family in the city park. Lit

[–] Guidy@lemmy.world 17 points 2 months ago

Hopefully it's not addictive, so maybe - just fucking maybe - people actually in pain can get it without jumping through a million hoops and being treated like drug-addicted criminals.

That'd be... neat.

[–] Trimatrix@lemmy.world 11 points 2 months ago (2 children)

I will bite. How much? Unless its cheaper than opiates, No one is going to put their profit margin above the common good of society.

[–] Mbourgon@lemmy.world 25 points 2 months ago (1 children)

“Vertex says that the medication will be available for $15.50 per 50-milligram pill, or about $30 per day. In contrast, comparable doses of the hydrocodone and acetaminophen combination retail for an average of about $7 per day.”

https://www.scientificamerican.com/article/what-is-journavx-the-new-opioid-free-painkiller-from-vertex/

[–] TheTechnician27@lemmy.world 15 points 2 months ago* (last edited 2 months ago) (1 children)

Alternative: send Vertex Pharmaceuticals' board to the guillotine and make the medication available for pennies per 50-milligram pill (at cost) or free (publicly funded).

[–] huppakee@lemm.ee 1 points 2 months ago (2 children)

Yes that will get people to do research and make new meds available. /s

[–] TheTechnician27@lemmy.world 21 points 2 months ago* (last edited 2 months ago) (2 children)

Should I have added "nationalize it and make future research funded and owned by the public"? (A lot of public funding already goes to medical research, but the profits get privatized.)

Private corporations researching medications so they can price gouge the chronically ill through a copyright-enforced monopoly isn't the only way to do medical research.

[–] Natanox@discuss.tchncs.de 2 points 2 months ago

That's the way.

[–] huppakee@lemm.ee -2 points 2 months ago

The public is definitely not benefitting enough from the research they fund als also the price gouging at the cost of sick people is very problematic, but I'm not in favour of beheading bad people. But I understand that the longer decision makers continue to allow these bad people to do these bad things, the more likely it becomes the guillotine makes an appearance.

[–] Doomsider@lemmy.world 4 points 2 months ago

Found the corporate bootlicker.

[–] Mouselemming@sh.itjust.works 9 points 2 months ago (1 children)

I think you (unintentionally) have that backwards. The companies absolutely will and do put their profit margin above the common good.

[–] Trimatrix@lemmy.world 2 points 2 months ago

Yeah…. My bad

[–] homesweethomeMrL@lemmy.world 8 points 2 months ago

What a weird site.

PR releases b/w standard blog fare and meta numbers discussion?

[–] Bluetreefrog@lemmy.world 7 points 2 months ago (1 children)

Aspirin has entered chat.

[–] ColeSloth@discuss.tchncs.de 3 points 2 months ago

Ah yes. The mild ache pain slightly less medication.

[–] ModestCrab@lemmy.wtf 6 points 2 months ago (4 children)

significantly more favorable side effect profile

So is this 3 days until an addiction starts vs the usual 2 days? Where’s the deets?

[–] 11111one11111@lemmy.world 17 points 2 months ago

It does but they didnt explain. It's the reduced impact on a person's brain that makes it less addictive by only blocking pain receptors at periphery locations and not in the brain. Removing the feeling of being high that opiates provide and just numbs the pain.

Journavx, which has been clinically proven to be as effective as opioids in the treatment of acute post-operative pain but with a significantly more favorable side effect profile. The drug blocks pain signals that are only found in the periphery, not in the brain, without the limitations of currently available therapies.

[–] don@lemm.ee 3 points 2 months ago (1 children)

There’s this at the bottom of the article. It may have what you’re looking for.

[–] ColeSloth@discuss.tchncs.de 2 points 2 months ago

I dont see it.

[–] DavidGarcia@feddit.nl 1 points 2 months ago (2 children)

I'll only make your dick fall off (and grow one first if you don't have one)

[–] Natanox@discuss.tchncs.de 5 points 2 months ago (1 children)

So it even doubles as non-invasive sex reassigment surgery precursor drug? Damn, this medicine is multifunctional as hell!

[–] captainlezbian@lemmy.world 1 points 2 months ago

The evolved form of spironolactone

[–] Laser@feddit.org 4 points 2 months ago

It's gonna be a huge success with Lemmy users

[–] captainlezbian@lemmy.world 4 points 2 months ago

Even if it had similar addiction profiles to opioids I'd be all for it. Opioid allergies are very common and those of us who have them also deserve to not be in agony after surgeries or physical trauma.

In fact, I worry that if its nonaddictive it may be pushed onto people who are allergic or nonresponsive to it similar to how nonstimulant adhd meds are. That doesn't mean I'm not all for nonaddictive painkillers, I'm 100% in favor and if we had a few options that can cover our bases I'd be in favor of shelving the poppy juice into a last resort role, but I hope people don't lose their sense of nuance in it.

[–] ripcord@lemmy.world 3 points 2 months ago

This does sound like great news.

[–] RizzRustbolt@lemmy.world 1 points 2 months ago

Is this BBB soluble like gabapentin?

[–] Swedneck@discuss.tchncs.de 1 points 2 months ago

so what, are normal pain relief pills opioids? or do they just not count as pain relief somehow?